Jiaogulan – The Best Antioxidant Supplement Available
Jiaogulan – The Best Antioxidant Supplement Available
Of all the antioxidant rich foods, teas, herbs, antioxidant vitamins and supplements in the world that have been studied by man, Jiaogulan is unlike any other and is by far the best antioxidant supplement that you can take.
This sounds like quite an extraordinary claim, and as the saying goes, extraordinary claims require extraordinary evidence.
Here we will provide you with such evidence and explain why saying Jiaogulan is THE best antioxidant supplement ever discovered is not an exaggeration, but a scientific fact.
Before we can see why Jiaogulan is an antioxidant unlike any other, we need to understand just what antioxidants are, their different types, and their function in the body.
What Are Antioxidants?
Antioxidants first became popular in the 1990’s, when scientists began to understand free radicals and the impact they have on our bodies.
Any compound or substance that can donate electrons and counteract free radicals is considered an antioxidant.
Therefore, antioxidants are intimately involved in the prevention of cellular damage caused by free radicals.
They are molecules that can safely interact with free radicals and neutralize them before they have the chance to damage vital cell parts.
Types of Antioxidants
There are two main types of antioxidants.
Those that are produced by the body itself are known as internal, or endogenous antioxidants.
The ones that come from outside sources like foods rich in antioxidant vitamins are know as external, or exogenous antioxidants.
Endogenous antioxidants are MUCH more powerful free radical fighters than exogenous ones.
Exogenous (External) Antioxidants
People in general are only aware of dietary antioxidants – the kind that can be found in foods like fruits and vegetables, drinks like green tea and coffee, and antioxidant supplements in the form of pills and capsules.
There are thousands of dietary antioxidants, but the most common ones are vitamins A, C, and E, lycopene, and beta-carotene.
Eating whole fruits, vegetables, and whole grains — all rich in networks of antioxidants and their helper molecules — protects against many diseases and premature aging.
And as we get older, it becomes more and more important to eat plenty of foods rich in antioxidants.
This is because our body’s natural defenses against free radicals diminish as we age, and so increasingly we need outside help in our battle against oxidation – the primary cause of disease and aging.
When you factor in environmental pollution, toxins, stress, and bad habits like smoking, proper diet becomes doubly important.
However, proper diet alone will eventually be insufficient and sooner or later we are all destined to succumb to the onslaught of free radicals.
Unless… (Hint hint: This is where Jiaogulan comes in! 🙂 )
While antioxidants can also be produced artificially and consumed in supplement form, studies on the effectiveness of supplements have been inconclusive.
It seems like they only provide limited benefits, if any, and in some cases can even be potentially harmful! 1, 2
Endogenous (Internal) Antioxidants
Few people are even aware of them, but endogenous antioxidants are your body’s natural and primary defense against free radicals.
There are 5 types of antioxidants produced by the body: superoxide dismatuse (SOD), alpha lipoic acid (ALA), coenzyme Q10 (CoQ10), catalase (CAT), and glutathione peroxidase (Gpx).
Of these, the three most important ones are SOD, Gpx, and CAT, in that order.
Endogenous antioxidants are literally hundreds and thousands of times more powerful free radical scavengers than ANY dietary antioxidant out there.
These antioxidants are the reason why when we are younger, we can be healthy even if we don’t know what a fruit or vegetable tastes like.
Unfortunately, our ability to produce them gradually decreases with age.
For years, scientists have sought ways to increase our levels of SOD and Gpx, since these are the most powerful antioxidants in existence.
While Gpx levels can be temporarily raised through special diet and exercise, the same cannot be said about SOD.
Clinical and Animal Studies
A number of clinical studies have now clearly demonstrated that Jiaogulan causes an increase of SOD, glutathione and catalase levels, and this has a number of beneficial and protective effects on our bodies.
These effects seem to become more important and pronounced as we get older.
Jiaogulan Is The Best Antioxidant Supplement
Jiaogulan’s remarkable ability to stimulate the body’s own production of both SOD and glutathione must be at the heart of the reason why it has been so strongly associated with anti-aging and longevity.
Science seems to have finally found the mechanism to explain how and why so many Jiaogulan users in China lived to be 100 years old in good health, and why they called it “The Herb of Immortality”.
We hope that it is now clear why we can confidently say that Jiaogulan is THE best antioxidant supplement anybody can take.
Jiaogulan is not like any other source of antioxidants, because it does not act in the same way as fruits, vegetables, vitamins, and other herbs.
Instead, its many saponins (the main active chemical compounds, also called gypenosides) have the ability to stimulate our bodies to produce the most powerful and vital antioxidants of all – the endogenous antioxidants superoxide dismutase, glutathione peroxidase, and catalase.
This is extremely important, because these endogenous antioxidants are either impossible (in the case of SOD), or difficult (in the case of Gpx and CAT) to obtain from our food.
Furthermore, since our ability to produce these endogenous antioxidants decreases dramatically with age, our bodies become increasingly defenseless against the onslaught of free radicals.
This eventually leads to age-related diseases and death.
These is no other substance ever discovered that can effectively stimulate the production of SOD, let alone ALL THREE of the most important and powerful free radical fighters.
Not only that, but Jiaogulan has been shown to restore SOD levels in elderly people to their youthful levels!
It is therefore not a stretch to say that Jiaogulan is a far superior antioxidant supplement than all other sources combined!
- The Alpha-Tocopherol, Beta Carotine Cancer Prevention Study Group (1994). “The effect of vitamin E and beta carotine on the incidence of lung cancer and other cancers in male smokers“.New England Journal of Medicine 330 (15): 1029–35. DOI:10.1056/NEJM199404143301501. PMID 8127329.
- Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A et al. (1996). “Effects of a combination of beta carotine and vitamin A on lung cancer and cardiovascular disease“.New England Journal of Medicine 334 (18): 1150–5. doi:10.1056/NEJM199605023341802. PMID 8602180.
- Maier CM, Chan PH. Role of superoxide dismutases in oxidative damage and neurodegenerative disorders. Neuroscientist. 2002 Aug;8(4):323-34.
- Fattman CL, Schaefer LM, Oury TD. Extracellular superoxide dismutase in biology and medicine. Free Radic Biol Med. 2003 Aug 1;35(3):236-56.
- Chung JM. The role of reactive oxygen species (ROS) in persistent pain. Mol Interv. 2004 Oct;4(5):248-50.
- Shin SG, Kim JY, Chung HY, Jeong JC. Zingerone as an antioxidant against peroxynitrite. J Agric Food Chem. 2005 Sep 21;53(19):7617-22.
- Zawadzka-Bartczak E. Activities of red blood cell anti-oxidative enzymes (SOD, GPx) and total anti-oxidative capacity of serum (TAS) in men with coronary atherosclerosis and in healthy pilots. Med Sci Monit. 2005 Sep;11(9):CR440-4.
- Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, Noble LJ, Yoshimura MP, Berger C, Chan PH, Wallace DC, Epstein CJ (December 1995). “Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase”. Nat. Genet. 11 (4): 376–81. doi:10.1038/ng1295-376. PMID 7493016.
- Tolmasoff JM, Ono T, Cutler RG. Superoxide dismutase: correlation with life-span and specific metabolic rate in primate species. Proc Natl Acad Sci U S A. 1980 May;77(5):2777–2781.
- Cutler, R.G. (1985) Peroxide-producing potential of tissues: Inverse correlation with longevity of mammalian species. Proc. Natl. Acad. Sci. U.S.A. 82, 4798–4802.
- Andersen HR, Jeune B, Nybo H, et al. Low activity of superoxide dismutase and high activity of glutathione reductase in erythrocytes from centenarians. Age Ageing. 1998 Sep;27(5):643-8.
- Micke P, Beeh KM, Buhl R. Effects of long-term supplementation with whey proteins on plasma glutathione levels of HIV-infected patients. Eur J Nutr. 2002 Feb;41(1):12-8.
- Lang CA, Mills BJ, Lang HL, Liu MC, Usui WM, Richie J Jr, Mastropaolo W, Murrell, SA. High blood glutathione levels accompany excellent physical and mental health in women ages 60 to 103 years. J Lab Clin Med. 2002 Dec; 140(6):380-1.
- IU Li-Bo, HU Bi, LIAO Duan-Fang; Protective effect of gypenosides on free radical damage of isolated guinea pig papillary muscles; Chinese Pharmacological Bulletin; 1993-04.
- Liu, Jialiu. “Effects of a gypenosides-containing tonic on the serum SOD activity and MDA content in middle-aged and aged persons.” Journal of Guiyang Medical College 19.1 (1994): 17.
- Lu, GH. et al. The effect of antioxidant herbs on the erythrocytic SOD activity and serum MDA content in patients with endemic fluorosis. Guizhou Medical Journal 1998; 22(3): 25.
- Zhang, XL et al. Study of the antioxidant effect of Danshen extract in aged persons and patients with fluorosis. Chinese Journal of Endemic Diseases. Chinese. 1998; 17(4):234.
- Ye Hong, Ma Yongxing, Xie Shuzhen, Gan Jiemin; Approaching the antisenescence effect of panglycoside extract of Gynostemma pentaphyllum(Thunb) Mak[J];Shanghai Medical & Pharmaceutical Journal;2001-11
- Li, L. and Lau, B. H. S. (1993), Protection of vascular endothelial cells from hydrogen peroxide-induced oxidant injury by gypenosides, saponins of Gynostemma pentaphyllum. Phytotherapy Research, 7: 299–304. doi: 10.1002/ptr.2650070408
- Yuan Quan, Yijun Yang, Huixing Wang, Bo Shu, Qi-hai Gong, Minzhang Qian. Gypenosides attenuate cholesterol induced DNA damage by inhibiting the production of reactive oxygen species in human umbilical vein endothelial cells. Molecular Medicine Reports. 12/2014; 11(4). DOI: 10.3892/mmr.2014.3095
- Zhou L, Xu YP, Wei Y, Shi XP, Liu CP. The effect of Gynostemma pentaphyllum (GP) on plasma lipoprotein metabolism and lipoperoxidation lipoprotein in the experimental hyperglycemia rats. Chinese Journal of Applied Physiology [2008, 24(2):205-208]
- L Li, L Jiao, B H Lau. Protective effect of gypenosides against oxidative stress in phagocytes, vascular endothelial cells and liver microsomes. Department of Microbiology, School of Medicine, Loma Linda University, CA. Cancer biotherapy 02/1993; 8(3):263-72. DOI: 10.1089/cbr.1993.8.263
- Lou Zhenling; Ma Liping; Zhang Xiaoqin, et al; Study on Biological Effects of Gynostemma Pentaphyllum Makino Polysaccharide (GPS)[J];Henan Journal of Oncology;1996-03
- WANG Qiugui; CHENG Yewen et al; Effects of Gynostemma Pentaphyllum on the Contents of SOD, GSH-PX, MDA, LDH and ATPase in Brain, Heart and Kidney of Severely Burned Rats[J];Journal Of Xianning Medical College;1999-04
- YAO Dan-dan,HUANG Shan-hua; Study on the anti-aging function of Gynostemma pentaphyllum Makino on sub-aging rats[J];Modern Journal of Integrated Traditional Chinese and Western Medicine;2007-28
- Cheng, YH et al. The effect of antioxidant Chinese herbs on SOD activity, MDA content and ultrastructural damage of the kidney tissue in mice with chronic fluorosis. Chinese. Guizhou Yiyao (Guizhou Medical Journal) 1998; 22(2): 94.
- Zhang, Guang-Lin et al. Gypenosides improve cognitive impairment induced by chronic cerebral hypoperfusion in rats by suppressing oxidative stress and astrocytic activation. Behavioural Pharmacology: October 2011 – Volume 22 – Issue 7 – p 633–644 doi: 10.1097/FBP.0b013e32834afef9
- L. Schild,T. Cotte,G. Keilhoff,R. Brodemann. Preconditioning of brain slices against hypoxia induced injury by a Gynostemma pentaphyllum extract – Stimulation of anti-oxidative enzyme expression. Phytomedicine: 15 June 2012, doi:10.1016/j.phymed.2012.03.012
- Jiang Enping et al. Protective effects of gypenosides on PC12 cell injury induced by oxidative stress. Human Health and Biomedical Engineering (HHBE), 2011 International Conference on, IEEE, 19-22 Aug. 2011, p.410-413 10.1109/HHBE.2011.6027986
- Wang P, Niu L, Gao L, Li WX, Jia D, Wang XL, Gao GD. Neuroprotective effect of gypenosides against oxidative injury in the substantia nigra of a mouse model of Parkinson’s disease. Journal of International Medical Research, 2010 May-Jun;38(3):1084-92.
- LIU Guohui,YAO Dandan,LU Jiayi,et al; The Effect Mechanism of Gynostemma Pentaphyllum Makino to Hippocampus in Aged Rats Induced by D-galactose;The Journal of Medical Theory and Practice;2006-05
- Yuan H et al. Gynostemma pentaphyllum protects mouse male germ cells against apoptosis caused by zearalenone via Bax and Bcl-2 regulation. Toxicology Mechanisms and Methods, 2010 Mar;20(3):153-8. doi: 10.3109/15376511003660185
- YAN Yan,GUO Jie,YANG Fei,XUE Wei; Anti-Oxidative Effect of Gynostemma and Hawthorn Extracts on the Aging Mouse Model Induced by D-galactose;Laboratory Animal Science;2009-03
- Chun-Ching Lin, Pei-Chen Huang, and Jer-Min Lin, Antioxidant and Hepatoprotective Effects of Anoectochilus formosanus and Gynostemma pentaphyllum. The American Journal of Chinese Medicine. 28, 87 (2000). DOI: 10.1142/S0192415X00000118
- Ye Zhenjun et al; Inhibitory Effect Of Gynostemma Pentaphyllum(Gp) On Liver Lipid Peroxidation Caused By Ccl_4;Industrial Health And Occupational Diseases;1998-02
- XIAO Zeng-ping, JI Ai-guo, SONG Shu-liang, LIANG Hao, LIU Ying-ying; Protective effects of Gynostemma Pentaphyllum polysaccharide on CCl_4-induced liver injury in mice; Chinese Journal of Biochemical Pharmaceutics;2008-03
- H. Huang, B. Qi, Protective Role of Polysaccharides from Gynostemma pentaphyllum Makino Supplementation against Exhaustive Swimming Exercise-Induced Oxidative Stress in Liver and Skeletal Muscle of Mice, Advanced Materials Research, Vols. 962-965, pp. 1231-1234, Jun. 2014
- Feng Q, Li X, Peng J, Duan X, Fu Q, Hu Y. Effect of gypenosides on DMN-induced liver fibrosis in rats. China Journal of Chinese Materia Medica, 2012 Feb;37(4):505-8.
- ZHANG Qing Bei, MA Jun Jiang, CHAO Zhi Xian, LIN Zhi Bin; Therapeutic role and its mechanism of gypenosides on delayed healing of experimental gastric ulcer induced by NCTC11637 strain HP in rats;Chinese Pharmacological Bulletin;1999-03
- YIN Ying,WU Jing-dong,GU Wei. The Chinese native medicine G.Pentaphyllum extraction resistance mouse skin senile experimental study. Chinese Journal of Aesthetic Medicine; 2008-06
- WANG Cai-xia,WANG Li-xin; The Experiment Study on Gynostemma External Skin Tissue on the Natural Aging Mice,CAT Activity,MDA Content; Journal of Practical Traditional Chinese Internal Medicine; 2011-07
- YAO Dandan, HUANG Shanhua, LIU Guohui; Effects of Gynostemma Pentaphyllum Makino on Hypothalamus in Aging Rats and Its Mechanisms; The Journal of Medical Theory and Practice; 2007-1
- Wang HongFang, Li ChangJun, Wu XiaoLan; Lou XiaoJuan; Effects of Gynostemma pentaphyllum (Thunb.) Makino polysaccharides supplementation on exercise tolerance and oxidative stress induced by exhaustive exercise in rats.; African Journal of Agricultural Research 2012 Vol. 7 No. 17 pp. 2632-2638
- Li ChangJun et al; Protective effects of crude polysaccharide from Gynostemma pentaphyllum on swimming exercise-induced oxidative stress in rat.; Journal of Animal and Veterinary Advances 2012 Vol. 11 No. 10 pp. 1627-1632
- Gao D, Zhao M, Qi X, Liu Y, Li N, Liu Z, Bian Y; Hypoglycemic effect of Gynostemma pentaphyllum saponins by enhancing the Nrf2 signaling pathway in STZ-inducing diabetic rats.; Archives of Pharmacal Research; 2014 Jul 29.
- Zhuohong Xie et al.; Chemical Composition of Five Commercial Gynostemma pentaphyllum Samples and Their Radical Scavenging, Antiproliferative, and Anti-inflammatory Properties.; Journal of Agricultural and Food Chemistry; 2010 Nov 10;58(21):11243-9. doi: 10.1021/jf1026372. Epub 2010 Oct 12.
- L. Schild et al.; Selective induction of apoptosis in glioma tumour cells by a Gynostemma pentaphyllum extract; Phytomedicine; Volume 17, Issues 8–9, July 2010, P. 589–597
- LIU Qing-qing, WU Jing-dong; Effect of Extract of Gynostemma on Activities of SOD and Capacity of Inhibiting OH in Blood of Naturally Senile Mice;Journal of Liaoning University of Traditional Chinese Medicine;2008-06
- Cai Taisheng, Zhang Shan-feng, Wang Ming-chen; Anti-oxidation effect of gypenosides in aged rats; Chinese Journal of Clinical Rehabilitation; 2005-35