Benefits of Jiaogulan and How It Works
Benefits of Jiaogulan and How It Works
I don’t know about you, but I’ve never met anyone who was both sick and happy.
Your greatest wealth is good health. It is fundamental for a happy and fulfilling life.
All the money and success in the world are meaningless if you don’t have your health.
You need to be healthy to fully appreciate the truly important things in life; spending quality time with your family and friends, playing ball with your children on a Sunday afternoon, or going on a vacation to a foreign country.
If you are like most people, chances are you’re overwhelmed and exhausted by the stress of the ever increasing pace and demands of everyday life.
Unfortunately, sooner or later the combination of stress, poor diet, lack of exercise and sleep, and chemical toxins in the environment will affect you and your health will decline.
Maybe you’re already one of the many millions of people around the world who suffer from heart problems, high cholesterol, high blood pressure, cancer, diabetes, low immune function, low libido, impotence, chronic fatigue, depression, mental decline and other neurological diseases?
If so, you’re probably taking expensive medications whose side effects are sometimes worse than the disease they’re supposed to control.
Maybe you’re worried that you’ll be one of the 30 something percent of people who are expected to get cancer in their lifetime?
Would you be interested in a natural and easy way to restore and maintain your overall health and well-being, to look and feel younger, relieve stress, have more energy, stamina, sexual vigor and mental clarity?
What if you could gain these benefits while at the same time preventing most of the diseases that plague our modern society?
Well, I have good news! A little known herb called Jiaogulan may just be your cup of healthy and delicious tea!
It can completely change life for you and your loved ones.
Keep reading to discover why many people say that if you had to pick just one supplement that would have the greatest overall impact on your health, you should choose Jiaogulan.
What is Jiaogulan?
Praised as “The Herb of Immortality” in China, Jiaogulan (Gynostemma pentaphyllum) is a climbing vine of the cucumber/gourd family, believed to contribute to a long and disease-free life due to its powerful anti-aging effects and possibly the widest spectrum of health benefits of any plant known to science.
Jiaogulan [is] an herb from my native southern China that I believe possesses the most wide-ranging benefits for human health and wellness of any plant yet discovered. This may seem like a bold statement, but having studied this remarkable tonic herb for more than twenty years, I can assure you that there is strong scientific support to back up my passion for jiaogulan.Dr. Jialiu Liu, 'Father of Jiaogulan'
The inhabitants of the high mountains of south central China have been using Jiaogulan for hundreds of years as a general health tonic and rejuvenating elixir. They have been drinking it daily as a tea before work to increase their endurance and strength, and after work to relieve fatigue and promote good sleep.
Jiaogulan (pronounced gee-ow-goo-lan) was largely unknown outside of those few remote mountainous regions until the early 1970’s when interest in Jiaogulan by the Chinese government was sparked by the results of the first nationwide population census, according to an article published in the Guangxi Daily Newspaper.1
The census revealed extremely low incidence of cancer, senility and other serious diseases, and an abnormally high percentage of people living to 100 years of age in certain villages of the Guizhou, Guangxi and Sichuan provinces.2, 3, 4
Interested in the reason for these intriguing results, the Chinese government commissioned a team of researchers from the Chinese Academy of Medical Sciences to conduct an investigation. The scientists considered genetics, climate, diet and many other factors.
They eventually found out that many of the centenarians consumed a tea made from a wild vine as a substitute for the traditional green tea. The locals called it “Xiancao”, or “The Immortality Herb”, and that served as a big hint for the scientists.
As a result of this discovery, and encouraged by promising research on Jiaogulan that had been going on in parallel in Japan since the early 70’s, the Chinese government appointed Dr. Jialiu Liu to lead a team of 16 scientists to investigate the properties of plants growing in the Mt. Fanjing Nature Reserve. After lengthy and extensive study of a large variety of herbs, they singled out Jiaogulan as the most promising plant for further research.
“After many years studying hundreds of herbs, we ultimately came to the realization that Jiaogulan was not only the rainforest’s most precious gift, but was in fact nature’s greatest treasure. We began to use Jiaogulan in our medical university hospital with great success for a wide variety of conditions, and before long, it was also being used at numerous other hospitals throughout China.”Dr. Jialiu Liu, 'Father of Jiaogulan'
Research into Jiaogulan over the past 40+ years has uncovered so many health benefits that at first it’s difficult not to react with disbelief. We provide references to a subset of the hundreds of scientific studies that support our claims, so you can examine them further if interested.
Jiaogulan’s health benefits are mostly due to it containing extremely high content of a class of plant chemicals known as saponins.
These saponins give Gynostemma its adaptogenic and antioxidant properties, as well as its ability to regulate Nitric Oxide production in the body.
Read on as we examine these properties in detail to see how Gynostemma is capable of making such a broad impact on your health by leveraging and mobilizing the body’s own innate intelligence and capacity for self-healing.
Jiaogulan the Adaptogen
Adaptogens are rare and remarkable plants that increase the body’s ability to counter and resist physical, chemical, biological, emotional, and environmental stressors by raising nonspecific resistance toward such stress. They decrease the organism’s susceptibility to illness by allowing it to “adapt” to the stressful circumstances.
Adaptogens support normal metabolism, help restore balance to the immune, nervous, and endocrine systems, and allow the body to maintain optimal homeostasis. They usually also benefit the liver, cardiovascular system, kidneys, and pancreas.
For a plant to be qualified as an adaptogen, it must meet the following 3 criteria as defined by Israel I. Berkhman, PhD, and Dr. I. V. Dardymov in 1968:
An adaptogen is nontoxic to the recipient. It must cause minimal side effects on physical or mental health.
An adaptogen produces a nonspecific response in the body—an increase in the power of resistance against multiple stressors including physical, chemical, or biological agents in multiple nonspecific ways, including the building of a reserve of “adaptive energy”. This reserve is then used when an actual stressor arises, instead of depleting the cells of vital energy.
An adaptogen is “intelligent” in that it has a normalizing influence on physiology, regardless of the direction of change from the normal state caused by the stressor. This normalizing influence implies the capability of adaptogens for a bidirectional effect on physiological function. They are capable of either toning down or strengthening the activity of multiple systems, including the neuro-endocrine and immune systems, depending on the need. For example, if a person with high blood pressure is given Jiaogulan, their blood pressure will drop. If on the other hand their blood pressure is below normal, it will raise.
When Dr. Berkhman was studying adaptogens, he discovered that the active compounds in most of them were a particular class of chemical compounds called triterpenoid saponins, which had very low toxicity and little addictive potential.
Some of these triterpenoid saponins have been identified as having adaptogenic properties, while others were found to have anti-inflammatory, hepatoprotective (protecting the liver), adrenal gland strengthening, and immune system modulating effects.2
Jiaogulan is a premier adaptogen, and has been described as “Like Ginseng, but better than Ginseng” because of the energizing effect both plants have on the body.
However, while Ginseng is often poorly tolerated and can cause insomnia, tachycardia and nervousness, Jiaogulan has the opposite effects because it is a superior adaptogen.
This is because while Panax Ginseng contains up to 28 different saponins5 (called panaxosides or ginsenosides), as of 2015 scientists have isolated 174 of them from Gynostemma (called gypenosides), nine of which are identical to those of Panax Ginseng.6,7
That’s over 6 times as many of these health-promoting and balancing chemicals!
In fact, Jiaogulan has the widest spectrum of saponins of any known plant in the world by far! This makes it a potentially more powerful and intelligent adaptogen with broader health effects than any other plant, and many have proclaimed it “The King of Adaptogens”.
Over 40 years of scientific research done so far on Gynostemma seems to support this possibility.
Jiaogulan the Supreme Antioxidant
For details on Jiaogulan’s Antioxidant properties, please see our Jiaogulan – The Best Antioxidant Supplement page.
Jiaogulan as a Nitric Oxide Regulator
Nitric Oxide (NO) is a gas and free radical produced in the body that is deemed so important in human physiology that it was named “Molecule of the Year” by the journal Science in 1992.58
Few people realize it, but Nitric Oxide is probably the most important chemical compound for cardiovascular health.
The President of the American Heart Association called it “the most important discovery in the history of cardiovascular medicine”, and in 1998, the Nobel Prize for Medicine was given to the three scientists who discovered the role of Nitric Oxide as a cardiovascular signalling molecule.
Simply put, adequate Nitric Oxide production is the first step in a chain reaction that promotes healthy cardiovascular function, while insufficient production triggers a cascade of destruction that eventually results in heart disease.
Nitric Oxide has been called a double-edged sword – or the Janus molecule, after the two-faced god – since it can be both vital and detrimental to your health and normal functioning.
At normal body concentrations Nitric Oxide is critically important for the proper functioning of all major body systems, including the cardiovascular, immune, nervous, and reproductive systems.
It enhances blood flow by dilating blood vessels, dissolving arterial plaques, and aiding in tissue recovery and regeneration. It helps brain nerve cells to communicate with each other and is involved in their development and regeneration. It also plays an important role in the fight against invading bacteria, viruses, and parasites.
However, Nitric Oxide concentrations that are too low or too high can result in a number of serious conditions and diseases like heart disease, stroke, cognitive decline, Alzheimer’s, Parkinson’s, autoimmune diseases, chronic inflammation, rheumatoid arthritis, gout, and many more.
Studies have now shown that Jiaogulan has the remarkable ability to both protect and stimulate the production of Nitric Oxide (NO) when your body produces too little of it6, 57, 59, 60, 61, or to limit its production when it is out of control38, 62, 63, 64.
Since diseases arise when Nitric Oxide levels are either too high or too low, the regulatory effect of Jiaogulan on its production is crucial in maintaining good health through balance, and is further testament to the herb’s adaptogenic properties.
Here is a short video by one of the discoverers of Nitric Oxide explaining the benefits of this molecule for your health.
We will explore the effects of Nitric Oxide on the various body systems in more detail throughout the rest of this article.
Jiaogulan Promotes Cardiovascular Health
Heart and blood vessel disease is the #1 cause of death in the world, resulting in 17.3 million annual deaths globally. In the United States it killed almost 800,000 people in 2013 alone.
The majority of problems classified under the umbrella of heart disease are related to a process called atherosclerosis, or thickening and hardening of the arteries. Atherosclerosis is a condition that develops when plaque, mostly made up of white blood cells and blood fats like cholesterol and triglycerides, builds up in the walls of the arteries.
This process starts when damage to the lining of the arteries – or endothelium – accumulates over time. It can be caused by high blood pressure (hypertension) and/or free radicals, for example as a result of smoking.
This arterial damage has a two-fold negative effect.
First, it results in a lower production of Nitric Oxide, which in turn leads to constriction of the arteries, higher blood pressure, more plaque formation, further arterial damage, and as a consequence even less Nitric Oxide production. This self-reinforcing cycle can spin out of control and lead to heart disease unless broken in some way.
Second, when the arteries get damaged they become stiffer and stickier over time. This makes them attract more “bad” LDL cholesterol and white blood cells, which then build up in the artery walls forming plaque.
The more cholesterol and fats there are in the blood (hyperlipidemia), the easier it is for arterial plaque to form. Buildup of plaque narrows the arteries and makes it more difficult for blood to flow through.
This can eventually lead to the formation of a blood clot (a process called thrombosis), which can completely block the blood flow and lead to heart attack, stroke, or embolism.
A heart attack or an ischemic stroke (the most common type) occurs when the blood flow to a part of the heart or brain, respectively, is blocked by a blood clot. If this clot cuts off the blood flow completely, the part of the heart muscle or brain supplied by that artery will die. This can lead to death or, in the case of stroke, to loss of ability to carry out normal functions like walking or talking.
In another type of stroke – haemorrhagic stroke – a blood vessel within the brain bursts. The most common cause is uncontrolled high blood pressure.
Other complications due to atherosclerosis include peripheral arterial disease, kidney disease, and erectile dysfunction.
What is truly remarkable about Jiaogulan is that it counteracts each of the individual causes of atherosclerosis mentioned above, and therefore at the very root it prevents and counters all the complications that come with it.
Jiaogulan Prevents Arterial Damage
As we already mentioned, damage to the arterial lining (endothelium) is THE key factor that leads to the development of atherosclerosis.
Jiaogulan prevents damage to the arterial lining in two ways.
First, it neutralizes the oxidative damage to the arteries caused by free radicals and cholesterol through its powerful antioxidant effects26, 27, 29 (see Antioxidant section).
The second way Gynostemma prevents endothelial damage is through its ability to regulate blood pressure, either lowering it 63, 65 or elevating it 63 depending on the need.
The herb’s ability to lower blood pressure is at least in part due to its protection and stimulation of endothelial Nitric Oxide production.6, 57, 59, 60
The primary function of endothelial Nitric Oxide is to widen the blood vessels (vasodilation), which increases blood flow circulation throughout your body, providing more of the oxygen and nutrients necessary for proper function of all tissues and organs.
Widening of the arteries has the effect of lowering blood pressure, since blood has more room to flow through and therefore less pressure is put on the arterial walls.
Without Nitric Oxide arteries constrict and require a higher blood pressure to maintain adequate blood flow to the tissue.
In addition, lack of Nitric Oxide increases the number of smooth muscle cells, which can also lead to higher blood pressure.
One double blind clinical study of patients with high blood pressure showed that Jiaogulan is almost as effective as Indapamide (a high blood pressure drug), and almost twice as effective as Panax Ginseng (82%, 93%, and 46% respectively) in reducing high blood pressure.65
Jiaogulan Prevents Plaque Buildup by Lowering Bad Cholesterol and Triglyceride Levels
Since LDL cholesterol and blood fats are the main ingredients of arterial plaque, a reduction of their concentration in the blood will help prevent or slow down the progression of atherosclerosis.
Jiaogulan has demonstrated its ability to lower bad cholesterol (LDL) and triglyceride levels, while raising good cholesterol (HDL) levels in a number of studies.18, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84
It achieves this by improving the body’s ability to metabolize fat and by stimulating Nitric Oxide production, which suppresses the damage done to bad (LDL) cholesterol by free radicals.
Lowering of the cholesterol levels also has a positive side effect of prevention of the formation of cholesterol gallstones.
Jiaogulan Prevents Platelet Stickiness and Blood Clots
Plaques grow over years and slowly blocks blood flow in the arteries. What’s worse, cholesterol plaque can suddenly rupture, especially where the person suffers from high blood pressure.
When a plaque inside a coronary artery ruptures, platelets (blood cells whose function is to stop the bleeding) become sticky, develop tentacles and start to roam around in gangs (platelet aggregation) and quickly make their way to the damaged area and pile on it until they either partially or completely block the artery.
The sudden blood clot that forms over the ruptured area causes the blood flow to stop, which results in a heart attack or stroke. Furthermore, blood clots can detach and travel into the blood stream until they get lodged in other blood vessels, for example in the lungs, causing an embolism.
Jiaogulan helps against the formation of blood clots by preventing the platelet aggregation process described above by increasing Nitric Oxide production – which reduces the stickiness of platelets – and by inhibiting Tissue Factor (TF) – the main protein needed for the blood clotting process to initiate.85
The herb has been shown to prevent the platelets from sticking together and to the lining of arteries in the first place, and also to help them detach from each other, or deaggregate, in both human clinical trials86 and animal studies87, 88, 89, 90, 91, 92, 93, 94.
Other Benefits of Jiaogulan to the Cardiovascular System
Jiaogulan reduces the affected area and the severity of injury to the brain and heart suffered as a consequence of a stroke or a heart attack, and accelerates the healing and recovery process.95, 96, 97, 98
The herb prevents heart muscle disease (cardiomyopathy) and protects heart muscles and their function from damage as a result of diabetes.99, 100
Jiaogulan also helps protect against coronary spasms, irregular heartbeat (arrhythmia), pressor response (the increase in arterial blood pressure in response to various internal or external conditions, e.g. drugs, mental stress, etc.), and ventricular tachycardia (a life-threatening rapid heart beat that starts in the bottom pumping chambers of the heart).101
Jiaogulan is beneficial for people who suffer from congestive heart failure because it improves the efficiency of the pumping action of the heart. This means the heart does not work as hard to produce the same amount of blood flow, helping it deliver more oxygen and nutrients to the body as a whole without causing additional stress. 102, 103
Jiaogulan and Cancer
Cancer is the second leading cause of death in the United States, killing almost 600,000 people in 2013 alone.
If you are an American, there is a one in three chance that you will get cancer during your lifetime. If you are a man, the odds are closer to one in two. Almost everyone in America either knows someone who currently has cancer or who has already died from cancer.
Arguably worse than the actual disease is the conventional treatment. Chemotherapy and radiotherapy are based on the principle that by poisoning and destroying the body as a whole, including its natural defenses against the disease (the immune system), the cancer will also be removed.
This is akin to deciding to carpet-bomb New York City, including its anti-terrorism and police departments, because there were “terrorist cells” discovered.
There are several problems with such a strategy:
- Chemotherapy and radiotherapy are so devastating to our body that the majority of people die as a result of the treatment and not the cancer itself.
- The root cause of the problem is not being addressed, so even if conventional treatments do succeed in removing the cancer, it will usually reappear in due time.
- It is extremely expensive financially, costing up to hundreds of thousands of dollars.
Because only the symptoms and not the root cause are addressed, multiple treatments will usually be necessary over the years, provided they work to begin with. How many of these “treatments” can your body survive?
To use another metaphor, imagine your body is an iron rod and the cancer is rust on that iron. If you don’t address the root cause of the rusting process, which is the presence of oxygen reacting with the iron, and only focus on removing the rust with a heavy-duty industrial grinder, how many times can you repeat this process before snapping the rod in two?
The answer of course depends on how thick the rod is, or how strong your body’s constitution is. Regardless, I’d bet the house you don’t want to find out.
Wouldn’t it be more sensible to apply a coating on the rod so that rust wouldn’t develop in the first place?
Wouldn’t it be better to instead strengthen the body and its defenses so that it can naturally prevent or fight the disease? After all, cancer cells are always present in our bodies and our immune system is usually perfectly capable of neutralizing them.
We believe this is a more sensible approach, and it seems mainstream science is starting to agree. So much so, in fact, that the journal Science has designated “Immunotherapy of Cancer” as its Breakthrough of the Year in 2013.
Research has shown that Jiaogulan has many cancer fighting and prevention effects on a wide variety of cancers.
It works on several levels to prevent and heal cancer:
- It enhances the body’s own defenses by protecting and boosting the immune system. A strong immune system is important for preventing the formation of tumors.
- With its exceptional antioxidant effects, Jiaogulan scavenges free radicals within the body, minimizing DNA mutations that lead to tumors. (See the Antioxidant section for more information)
- Its chemical components like saponins (gypenosides), flavonoids and polysaccharides have direct anticancer action.
Jiaogulan has been shown in studies to reduce tumor size, inhibit tumor growth and metastasis (spreading), cause apoptosis (tumor cell death) by increasing free-radical damage to cancer cells, and inhibit energy production in cancer cells.
These effects have been demonstrated in several types of cancer, including:
- Liver (hepatoma)104, 105, 106, 107, 108, 109, 110, 111, 112, 113
- Lung114, 115, 116, 117, 118, 119, 120
- Colorectal122, 123, 124, 125
- Esophageal 122, 126
- Oral127, 128, 129, 130, 131, 132, 133, 134, 135
- Stomach 137, 138
- Skin (melanoma)139, 140
- Uterus/cervix141, 142, 143
- Leukaemia 144, 145, 146, 147
- Sarcoma 147, 148
For those who choose to use the traditional methods of cancer treatment – chemotherapy and radiation therapy – Jiaogulan has shown to be an invaluable ally.
This is because it provides a very strong protection against the damaging effects these treatments have on the immune system.149, 150, 151, 152, 153, 154
Jiaogulan was also found to diminish the overall damaging effects of drug toxicity from chemotherapy137, 148, while at the same time boosting its effectiveness125, 148.
A Word of CautionWhile Jiaogulan’s cancer-fighting properties are indisputable, we do not recommend using it as a stand-alone cancer treatment.
However, we wholeheartedly recommend that you use it for cancer prevention and as an add-on therapy to any treatment, conventional or otherwise.
Jiaogulan Slows Down Aging and Increases Longevity
Longevity isn’t just about reaching a ripe old age – it’s also about feeling and looking good as you get there!
While most people today choose anti-aging creams, surgery, and Botox, we believe in a more holistic approach to health and aging because youth, like beauty, is more than skin deep.
Jiaogulan was first discovered in China because of the unusually long life spans and good health of so many of its users in the mountainous regions where it grows.
When you drink Jiaogulan tea daily you will not only look younger, you will be younger and healthier.
The herb slows down aging from the inside out. It has a rejuvenating and healing effect on all organs and major systems due to its unrivaled ability to neutralize the free-radicals that damage and age your body by boosting production of the two most important endogenous antioxidants – superoxide dismutase (SOD) and glutathione.
These two antioxidants are crucial in preventing aging and promoting longevity. Please see the section on the Antioxidant properties of Jiaogulan for details and more scientific evidence.
In human clinical studies, administration of Jiaogulan three times daily for two months was beneficial for all 106 patients (in the study) in reducing general signs and symptoms of aging, such as fatigue, lack of energy, aversion to cold, diarrhoea, poor memory, decreased balance, insomnia, and excessive dreams.155
Studies with aging animals have shown that Jiaogulan improves their memory and learning ability 156, and rejuvenates their skin47, 48, 157. It was also found that the herb increases the thickness of the skin, boosts synthesis of collagen, and protects elasticity158. For extra skin benefit, you can also apply Jiaogulan tea topically, for example as a face rinse.
In addition, there have now been several studies that support claims the herb increases longevity.
In one study, a group of old mice were divided into two groups. After four months, all mice in the control group died, while only 50% of the mice in the Jiaogulan group died.159
In another study, the lifespan of fruit flies was increased by as much as 50% when given Jiaogulan.160 Other animal studies have also demonstrated increase in lifespan.161, 162
Jiaogulan Prevents and Fights Diabetes Mellitus
For details on Jiaogulan’s benefits for Diabetes, please see our Jiaogulan and Diabetes page.
Jiaogulan Protects and Boosts the Immune System
Numerous human and animal studies have shown Jiaogulan to protect and strengthen the immune system function.
The immune system is a network of cells, tissues, and organs that work together to protect the body from infection and disease.
It is your body’s only natural defense against viruses, bacteria, parasites, and diseases like cancer.
It is hardly surprising that a strong and properly functioning immune system is crucial to lasting good health.
Jiaogulan’s beneficial effects on the immune system are mostly due to its antioxidant properties and ability to balance Nitric Oxide production.
Nitric oxide regulates the functional activity, growth and death of many immune and inflammatory cell types. Certain immune cells produce it in high enough concentrations for it to become toxic and use it as a weapon against invading bacteria, viruses, parasites, as well as to defend against tumors.
However, under certain conditions this process can backfire, resulting in the production of too much Nitric Oxide by the immune system. This can cause a variety of problems, including inflammation, sepsis, and autoimmune diseases.
Jiaogulan’s ability to reduce Nitric Oxide when the immune system is overactive is therefore vital in the prevention of inflammatory and autoimmune diseases, including some cancers, rheumatoid arthritis, gout, heart disease, periodontitis, and hay fever.
The herb also fights inflammation by decreasing free radical damage and inhibiting Nuclear Factor-kappaB (NF-kB) – a protein involved in cell survival and signaling – both important factors in the generation of inflammation.30, 32, 62, 93, 94, 178, 179, 180, 181
As an antioxidant, the herb protects the integrity of the immune system from free radicals and environmental toxins 26, 30, 32
Gynostemma also protects the immune system from the effects of stress 6, rigorous or exhaustive physical exercise 182, 183, 184, and cancer chemotherapy and radiation therapy149, 150, 151, 152, 153, 154.
Finally, Jiaogulan increases the potency of the immune response to foreign invaders, toxins,6, 30, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196 and cancer 118, 119, 138, 139, 186.
Jiaogulan Protects and Strengthens the Nervous System
Jiaogulan protects and enhances the function of the central and peripheral nervous systems, mainly through its antioxidant properties and its ability to regulate Nitric Oxide production.
Nitric Oxide plays an important role in learning and memory by helping nerve cells in the brain to communicate with each other.197, 198 It is involved in neurotransmitter release, neural development and regeneration, synaptic plasticity and regulation of gene expression.199
At normal concentrations, Nitric Oxide protects the nerve cells from damage and cell death. However, at high concentrations it becomes toxic to the nerve cells and can cause cell injury and cell death.200
Overproduction of Nitric Oxide in the nervous system has been linked to Alzheimer’s disease, Parkinson’s disease, multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Huntington’s disease, and depression.201
In addition, free radical damage has been shown to play a major role in the development of neurodegenerative diseases such as Alzheimer’s and Parkinson’s.202, 203
In light of this, it’s not surprising that Jiaogulan has been shown to help prevent both Alzheimer’s 204, 205, 206, 207 and Parkinson’s 37, 208, 209, 210, 211, 212, which are the 6th and 14th leading causes of death in the United States respectively. It may also be effective against optic neuritis, although further studies are needed.213
In both human and animal studies, Gynostemma was shown to improve brain functions like memory, concentration, and learning, especially with the elderly.156, 214, 215, 216
The herb also helps protect against and recover from brain and memory damage induced by alcohol217, 218 and free radicals31, 34, 35, 36, 37, 38, 49, as well as damage and cognitive impairment from ischemia-reperfusion and hypoxia due to stroke and other causes.34, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227
A study with elderly cerebral infarction patients (a type of ischemic stroke) showed that administering Jiaogulan for a 12-week period improved their cognitive functions to a level close to that of normal elderly subjects who had not suffered a stroke. In addition, the improvements were better than that of a control group that was given Piracetam, a popular nootropic and brain-enhancing drug.228
A second clinical study using different evaluation methods showed identical results, and further improvement when treatment was continued for 12 more weeks (24 weeks in total).229
Jiaogulan can also prevent brain and nervous system damage caused by consumption of the popular flavor enhancing food additive Monosodium Glutamate (MSG).230, 231, 232, 233
Lastly, the herb was found to increase the excitability and stability of the brain during athletic competition. A Guiyang Medical College research group carried out testing on more than 300 professional athletes, including athletes of the China National Skating Team. All of the tested athletes reported that a Jiaogulan/Danshen recipe taken before the competition made them vigorous and alert, with quick reflexes and less nervousness. A control group taking Danshen alone did not feel increased stability and excitability of the nervous system during competition, although they also felt increased energy and endurance.234, 235
Jiaogulan Improves Athletic Performance
Many top athletes and bodybuilders use Jiaogulan because it enhances their performance by energising the body and increasing physical strength, stamina, endurance and muscle tone.
This is also why Jiaogulan is given to race-horses.
If you’re involved in sports or workout at the gym, you will find that you can go through your usual training routine with less effort, or that you can endure a harder workout by only expending the same amount of effort as you did before.
Jiaogulan is able to increase athletic performance in several ways:
- By regulating the production of Nitric Oxide.
- By improving heart function efficiency.
- By stimulating the production of the endogenous antioxidants glutathione and superoxide dismutase.
Since one of the main functions of Nitric Oxide is to widen the arteries (vasodilation), it has the effect of increasing blood circulation throughout the body. This provides more of the oxygen and glucose the muscles need to be able to work at peak levels longer, improving stamina and energy levels.
Nitric Oxide also stimulates growth hormone production236, which encourages fat reduction and muscle building.
Jiaogulan also improves the efficiency of the pumping action of the heart, so that it doesn’t work as hard to produce the same amount of blood flow. Again, more oxygen and nutrients reach the muscles and performance is improved.
A clinical study at the Guiyang Medical College with 30 normal healthy persons and 220 athletes showed that within 30 minutes after oral administration of a single dose of Jiaogulan combined with other Chinese medicinal herbs, all subjects responded with increased cardiac output and stroke volume, while heart rate and blood pressure did not change.237
Animal studies have confirmed this positive effect on heart function and have concluded that Jiaogulan’s effect is more potent than that of ginseng 103, 238
A number of studies involving forced swimming tests with animals have proven that Jiaogulan has a significant anti-fatigue effect and increases the endurance capacity in animals, enabling them to swim significantly longer before they get exhausted. In addition, these effects become stronger as the dose is increased.239, 240, 241, 242, 243, 244, 245, 246
Jiaogulan significantly increases glucose levels in the blood, liver and muscles, which is the fuel the muscles use and is therefore very important for the prolongation of endurance exercise.
Furthermore, Gynostemma decreases the amount of lactic acid (the build-up of which causes sore muscles the day after rigorous exercise) in the blood significantly and this is an important indicator for judging the degree of fatigue and means that Jiaogulan is able to postpone the appearance of fatigue and accelerate the recovery from fatigue.239, 240, 241, 242, 243, 244
In parallel, the levels of uric nitrogen in the blood are decreased 241, 242, 243, 244, 245, 246, which means that not as much protein needs to be digested in order to produce energy.
Jiaogulan also helps us reach peak mental and physical function by boosting the levels of the endogenous antioxidants superoxide dismutase (SOD) and glutathione, and lowering Malondialdehyde (MDA).241, 243, 244, 245, 246, 247, 248, 249, 250 This means less muscle damage resulting from exercise, quicker recovery time, increased strength, endurance and a shift in the metabolism from fat production to muscle development.
Finally, Gynostemma is able to regulate immune function during exercise, recovering immune indices to normal values from either originally lower or higher than the normal.182, 183, 184
This is important because it has been demonstrated that the immune system is suppressed after rigorous exercise. Marathon runners and the high frequency of respiratory tract infections immediately after a run are one example.
If you are involved in physical exercise, act like the pros and have some Jiaogulan before a workout for extra energy and stamina, and after workout to help your body repair more quickly from the damage physical exercise inevitably causes.
Other Health Benefits of Jiaogulan
Being an adaptogen, Jiaogulan reduces mental and physical stress. It has also been shown to have a significant anxiolytic (anti-anxiety) effect and to help recover dopamine and serotonin levels back to normal.6, 211, 251, 252, 253, 254One double-blind placebo-controlled human clinical trial demonstrated the herb’s ability to significantly reduce anxiety and stress in groups of high anxiety and normal individuals by over 20% and 10% respectively, as evaluated by standard anxiety and stress tests.255Jiaogulan has also shown promise in the treatment of depression.256
Jiaogulan helps reduce weight in overweight people, at least in part by activating AMP-activated protein kinase (AMPK).257, 258 In addition, the herb’s ability to increase insulin sensitivity in the body also has beneficial weight-stabilizing or weight-loss effects.259A 12-week, randomized, double blind, placebo-controlled clinical trial was done with 80 participants who were considered obese according to Asia-Pacific guidelines. 40 subjects were given an extract of one of Jiaogulan’s active ingredients and 40 were given placebo. The subjects made no changes to their lifestyle. Body weight in the Jiaogulan group dropped by 1.35kg, fat mass dropped by 1.25kg, and waist circumference dropped by 2.62 centimeters on average. None of these changes were observed in the placebo group.260A second randomized, single-blind, placebo-controlled clinical trial involving 56 subjects who were diagnosed with non-alcoholic fatty liver also found statistically significant effect of Jiaogulan extract on Body Mass Index (BMI), as well as improvements in other parameters over the placebo group.261Jiaogulan has also been reported to help those who are underweight to gain mass by improving metabolism and nutrient absorption. However, no studies have yet been done to test this claim.
Jiaogulan has been widely reported to protect and cleanse the body from toxins.294, 295, 296 The herb is able to do that by stimulating the production of the antioxidant glutathione, which plays a vital role in detoxifying the body by binding to pesticides, heavy metals and other toxins until they are excreted.
Jiaogulan was found to completely cure Hepatitis B in a 5.5 years long clinical trial with an effective rate of 77.5%.262 In short-term clinical studies (3 months or less), Jiaogulan was also found to have positive effect on patients with a chronic hepatitis B infection.263, 264Prevents liver fibrosis – a scarring process that represents the liver’s response to injury – which can lead to cirrhosis of the liver, liver failure and liver cancer.45, 265, 266, 267, 268, 269, 270Effective both as a stand-alone treatment for non-alcoholic fatty liver disease caused by high fat and cholesterol diet271, and as an add-on treatment in a 6 month long human clinical study261. Jiaogulan prevents liver fatty degeneration in fatty liver disease by modulating fat metabolism, ameliorating liver dysfunction, reducing oxidative stress272, and protecting liver cells from injury and death61.Protects against liver damage and cell death caused by ischemia/reperfusion via its antioxidant activity.273
Three separate clinical studies with hundreds of patients suffering from chronic renal failure showed that Jiaogulan can decrease blood fats and improve kidney function, anemia, and the nutritional situation in these patients.274, 275, 276Protects the kidneys from damage due to toxins.277Suppresses the development of renal fibrosis.278, 279Protects against kidney failure and gout by lowering blood uric acid in cases of hyperuricemia (abnormally high level of uric acid in the blood), which can cause both of these conditions.280
Jiaogulan is effective against respiratory issues, such as cough, asthma, chronic bronchitis, and chronic tracheitis (inflammation of the trachea).191, 196, 281, 282, 283, 284In a clinical study of 86 patients with chronic bronchitis, Jiaogulan was found to effectively treat 93% of the cases.285In another clinical study of 96 cases, Jiaogulan was effective 92% in treating chronic bronchitis.286The herb is used traditionally as an expectorant and decongestant since it helps clear mucus from the airways, lungs, bronchia and trachea.196
Jiaogulan protects the GIT from damage due to toxins277 and improves digestion and metabolism. It protects against and heals gastric ulcers46, 287, as well as chronic atrophic gastritis288.It improves bowel movement function and alleviates constipation. Helps regulate the gut microbiome ecosystem by increasing the number of symbiotic bacteria. This may in part contribute to the anticancer effect of Gynostemma, since the gut ecosystem can play an important role in diseases such as cancer, autism, rheumatoid arthritis, and allergies.289
Jiaogulan normalizes and regulates the endocrine/hormonal system, especially adrenal function.2, 300
Jiaogulan improves sexual function and helps with Erectile Dysfunction because it regulates Nitric Oxide production. Nitric Oxide plays a key role in developing and maintaining penile erection due to its ability to dilate the arteries and increase blood flow to the whole body, including the penis.209, 290, 291
Increasing Nitric Oxide production is the biological basis of how the popular drug Viagra works.Nitric Oxide is also important in sperm production and motility, ovarian function and ovulation, oviduct (the tube that links the ovary to the uterus) function, formation of the placenta, pregnancy, labor, sexual behavior, and generation of steroid hormones.292Jiaogulan has been shown to protect the sperm from damage due to toxins39 and high blood fat content293.
Gynostemma has been used as an effective treatment for insomnia in folk medicine, especially when it occurs because of excessive stress or anxiety. This is because it soothes the nerves and has anti-stress and anxiety effects on the body. A Guiyang Medical College study with 112 patients showed that Jiaogulan could improve sleep with an effective rate of 89 – 95%.297
Jiaogulan has been shown to protect from UV radiation when applied directly to the skin.157, 298, 299 Even if consumed only as a tea, the herb will still have a protective effect against sunburn because it’s a powerful antioxidant. This is important in the prevention of melanoma (skin cancer) and premature aging of the skin.
Jiaogulan has shown promise in the treatment of Psoriasis, a chronic inflammatory skin disorder.301
Jiaogulan has been shown to alleviate headaches and migraines.306
If you ever find you’ve had a few too many drinks the night before, have a couple of cups of Jiaogulan tea in the morning – you’ll be pleasantly surprised!
Jiaogulan is Completely Safe and Non-Toxic
The fact that people have safely been using Jiaogulan daily for hundreds of years in China without reporting any negative side effects should be convincing enough that the herb has no toxicity.
In addition, however, there is also a great deal of scientific research that demonstrates its safety.
Of the many hundreds of scientific studies on Jiaogulan, a significant number of which have checked for toxicity or adverse side-effects, there has never been a report of any toxic effects whatsoever to any organ in the body.
Furthermore, there have been several studies whose specific purpose was to find any signs of toxicity from Gynostemma, as well as determine the LD50 (the dose necessary to cause death to 50% of test animals).
In one study Wistar rats were given up to 750mg per kilogram of Jiaogulan extract orally every day for 6 months. No toxic effects were observed.307 The results of another 4-month study with 1000mg/kg daily oral dose were identical.308
One study could not determine a LD50309, while another determined it to be at 49 grams of extract per kilogram of body weight, with no organ toxicity at 4 g/kg daily intake for 90 days.310
Considering that the daily recommended dose is usually somewhere between 50-300 milligrams of gypenosides per day, it would be literally impossible for a human to consume enough Jiaogulan to get anywhere near these concentrations even if they tried extremely hard.
Contrast this to prescription drugs people use every day, which cause 106,000 deaths per year in the United States alone! And that does not take into consideration the serious side effects of these drugs even if they don’t kill you.311
Majestic Herbs Jiaogulan is 100% Organic
Our Jiaogulan tea has no additives, no chemicals, no coloring, no flavorings, no sugar, no caffeine, no herbicides, no pesticides and is 100% non-GMO.
Our Jiaogulan is grown by small farmers in a pristine high mountain region, designated a national park by the Royal Family and Government of Thailand. No pesticides or other chemicals are allowed or used in the farming process.
In addition, Jiaogulan is naturally resistant to pests, so pesticides are not necessary.
Majestic Herbs Jiaogulan is 100% Organic
Our Jiaogulan tea has no additives, no chemicals, no coloring, no flavorings, no sugar, no caffeine, no herbicides, no pesticides and is 100% non-GMO.
Our Jiaogulan is grown by small farmers in a pristine high mountain region, designated a national park by the Royal Family and Government of Thailand. No pesticides or other chemicals are allowed or used in the farming process.
In addition, Jiaogulan is naturally resistant to pests, so pesticides are not necessary.
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